Boron Neutron Capture Therapy for Cancer: Future Prospects in Indonesia
AJSTD 35(3)


Targeting therapy


Boron neutron capture therapy (BNCT) is a form of cancer therapy based on the interaction of low-energy thermal neutrons and boron-10 (10-B) to produce alpha radiation from He-4 and Li-7 with a high linear energy transfer. A beam of neutrons irradiates a boron drug injected into the tumor, resulting in the boron-injected cancer cells receiving a lethal dose of radiation with the surrounding, healthy cells being minimally affected. Two boron drugs have been used clinically in BNCT, boron sodium captate (BSH) and borophenylalanine (BPA), while a third, pentagamaboronon-0 (PGB-0), is currently under development in the Faculty of Pharmacy of Universitas Gadjah Mada, Indonesia. In Indonesia, there has been a growing interest in the study and use of BNCT to treat cancer, as this method is expected to be safer and more effective than traditional cancer treatment methods.


Akan Z, Demiroglu H, Avcibasi U, Oto G, Ozdemir H, Deniz S,Basak AS. 2014. Complexion of boric acid with 2-deoxy- d-glucose (DG) as a novel boron carrier for BNCT. Med Sci Discovery. 1(3):65. doi:10.17546/msd.74442.

American Cancer Society. 2016. Chemotherapy side effects. d-side-effects/treatment-types/chemotherapy/ch emotherapy-side-effects.html.

Barth RF, Soloway AH, Fairchild RG. 1990. Boron neutron capture therapy of cancer. Cancer Res. 50(4):1061–1070.

Horiguchi H, Nakamura T, Kumada H, Yanagie H, Suzuki M, Sagawa H. 2011. Investigation of irradiation conditions for recurrent breast cancer in JRR-4. Appl Radiat Isot. 69(12):1882–1884. doi:10.1016/j.apradiso.2011.03.036.

[IARC] The International Agency for Research on Cancer.2013. Latest world cancer statistics - Global cancer burden rises to 14.1 million new cases in 2012: Marked increase in breast cancers must be addressed. Press release No. 223.

Manuaba I, editor. 2010. Panduan Penatalaksanaan Kanker Solid PERABOI 2010. Jakarta: Sagung Seto.

Menichetti L, Gaetano L, Zampolli A, Del Turco S, Ferrari C, Bortolussi S, Stella S, Altieri S, Salvadori P, Cionini L. 2009. In vitro neutron irradiation of glioma and en- dothelial cultured cells. Appl Radiat Isot. 67(7-8):S336–S340. doi:10.1016/j.apradiso.2009.03.058.

Ministry of Health. 2016. Pro?l kesehatan Indonesia tahun 2015 [Indonesia’s health statistics 2015]. Technical re- port. Ministry of Health Republic of Indonesia. http: // Hasil%20Riskesdas%202013.pdf.

[NIHRD] National Institute of Health Research and Devel-opment. 2013. Riset kesehatan dasar [Basic health re- search]. Technical report. Ministry of Health Republic of Indonesia. ownload/general/Hasil%20Riskesdas%202013.pdf.

Wahidin M, Noviani R, Hermawan S, Andriani V, Ardian A, Djarir H. 2012. Population-based cancer registration in Indonesia. Asian Pac J Cancer Prev. 13(4):1709–1710. doi:10.7314/APJCP.2012.13.4.1709.

[WHO] World Health Organization. 2014. WHO - Cancer country pro?les Indonesia 2014. Geneva: World Health Organization.

Yanagie H, Kumada H, Sakurai Y, Nakamura T, Furuya Y,Sugiyama H, Ono K, Takamoto S, Eriguchi M, Takahashi H. 2009. Dosimetric evaluation of neutron capture therapy for local advanced breast cancer. Appl Radiat Isot. 67(7-8):S63–S66. doi:10.1016/j.apradiso.2009.03.1 10.
Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Copyright (c) 2018 Array


Download data is not yet available.