Boron neutron cancer therapy is a cancer treatment method that encompasses epithermal neutron irradiation of boron delivered to tumor cells. Using collimators, fast neutrons are moderated into epithermal neutrons. When radiation is performed, neutron beams are emitted and filtered by a collimator. In this study, 12 collimators used in the BNCT process were inspected for their quality, in terms of defects or flaws. The inspected collimators were manufactured by centrifugal casting and were composed of 99% pure nickel. They had the following dimensions: height of 145 mm, outer diameter of 190 mm, inner diameter of 160 mm, and thickness of 15 mm. The inspection method used was gamma radiography testing with an Iridium-192 gamma source. Using a single wall single image technique, the collimators were exposed for 30 seconds. Six FUJI films were placed behind the object to record the resulting images, which showed light or dark areas on each collimator, the latter of which indicated porosity or flaws. Based on these images, collimators 1 and 5 were found to contain cracks, and porosity was identified in almost all of the collimators. It is suggested that both collimators with cracks be recycled, while the collimators with porosities should be investigated further to determine their suitability for boron neutron cancer therapy.
American Society of Mechanical Engineers. 2013. ASME boiler and pressure vessel committee on nondestructive examination. New York: American Society of Mechanical Engineers.
Bavarnegin E, Kasesaz Y, Wagner FM. 2017. Neutron beams implemented at nuclear research reactors for bnct. J Instrum. 12(5):P05005. doi:10.1088/1748-0221/12/05/P0500.
Ben Gharsallah M, Ben Braiek E. 2015. Weld inspection based on radiography image segmentation with level set active contour guided off-center saliency map. Adv Mater Sci Eng. 2015:1–10. doi:10.1155/2015/871602.
Bilalodin, Kusminarto, Hermanto A, Sardjono Y, Sunardi. 2017. Double layer collimator for BNCT neutron source based on 30 MeV cyclotron. Indones J Phys Nucl Appl. 2(3):124. doi:10.24246/ijpna.v2i3.124-127.
Brandão SF, Campos TPR. 2009. Dosimetric analysis of BNCT - boron neutron capture therapy - coupled to 252cf brachytheraphy. Paper presented at: 2009 International Nuclear Atlantic Conference; Rio de Janeiro, Brazil.
Dwivedi SK, Vishwakarma M, Soni A. 2018. Advances and researches on non destructive testing: A review. Mater Today: Proc. 5(2):3690–3698. doi:10.1016/j.matpr.2017.11.620.
Ebhota WS, Karun AS, Inambao FL. 2016. Centrifugal casting technique baseline knowledge, applications, and processing parameters: overview. Int J Mater Res. 107(10):960–969. doi:10.3139/146.111423.
Elfahmi NV, Woerdenbag HJ, Kayser O. 2014. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J Herb Med. 4(2):51–73. doi:10.1016/j.hermed.2014.01.002.
Fantidis JG, Nicolaou G. 2018. Optimization of beam shaping assembly design for boron neutron capture therapy based on a transportable proton accelerator. Alexandria Eng J. 57(4):2333–2342. doi:10.1016/j.aej.2017.08.004.
Gholizadeh S. 2016. A review of non-destructive testing methods of composite materials. Procedia Struct Integr. 1:50–57. doi:10.1016/J.PROSTR.2016.02.008.
Hassanpour SH, Dehghani M. 2017. Review of cancer from perspective of molecular. J Cancer Res Pract. 4(4):127–129. doi:10.1016/J.JCRPR.2017.07.001.
International Atomic Energy Agency. 1996. Manual on gamma radiography. Vienna: International Atomic Energy Agency. https://gnssn.iaea.org/CSN/TM%2048337%20Industrial%20Radiography/Reference%20Material/IAEA%20Practical%20Radiation%20Safety%20Manual%20on%20Gamma%20Radiography.pdf.
International Atomic Energy Agency. 2001. Current status of neutron capture therapy. Vienna: International Atomic Energy Agency. https://pub.iaea.org/MTCD/Publications/PDF/te_1223_prn.pdf.
Lage A, Romero T. 2018. Back and forth between cancer treatment and cancer control programs: insights from the Cuban experience. Semin Oncol. 45(1-2):12–17. doi:10.1053/J.SEMINONCOL.2018.04.004.
Lopez A, Bacelar R, Pires I, Santos TG, Sousa JP, Quintino L. 2018. Non-destructive testing application of radiography and ultrasound for wire and arc additive manufacturing. Addit Manuf. 21:298–306. doi:10.1016/j.addma.2018.03.020.
Maitz CA, Khan AA, Kueffer PJ, Brockman JD, Dixson J, Jalisatgi SS, Nigg DW, Everett TA, Hawthorne MF. 2017. Validation and comparison of the therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes in multiple murine tumor models. Transl Oncol. 10(4):686–692. doi:10.1016/j.tranon.2017.05.003.
Mgonja CT. 2017. Evaluation on use of industrial radiography for weld joints inspection in Tanzania. Int J Mech Eng Technol. 8(5):65–74.
Mujiyono, Suharto, Mukhammad AFH, Nurhadiyanto D, Sumowidagdo AL. 2018. Manufacture of nickel collimator for BNCT: smelting of nickel using electrical arc furnace and centrifugal casting preparation. Indones J Phys Nucl Appl. 3(1):21–28. doi:10.24246/ijpna.v3i1.21-28.
Nedunchezhian K, Aswath N, Thiruppathy M, Thirugnanamurthy S. 2016. Boron neutron capture therapy - a literature review. J Clin Diagn Res. 10(12):1–4. doi:10.7860/JCDR/2016/19890.9024.
Nurhadiyanto D, Mujiyono, Ristadi FA. 2017. The characteristics of aluminum casting product using centrifugal casting machine. International Conference on Technology and Vocational Teachers (ICTVT 2017). Paris: Atlantis Press. p. 153–158. doi:10.2991/ictvt-17.2017.27.
Payudan A, Aziz AN, Sardjono Y. 2016. Basic principle application and technology of boron neutron capture cancer therapy (BNCT) utilizing Monte Carlo N Particle 5’s software (MCNP 5) with compact neutron generator (CNG). Indones J Phys Nucl Appl. 1(1):20. doi:10.24246/ijpna.v1i1.20-33.
Sarfati D, Garvey G, Robson B, Moore S, Cunningham R, Withrow D, Griffiths K, Caron NR, Bray F. 2018. Measuring cancer in indigenous populations. Ann Epidemiol. 28(5):335–342. doi:10.1016/J.ANNEPIDEM.2018.02.005.
Sudhakar A. 2009. History of cancer, ancient and modern treatment methods. J Cancer Sci Ther. 01(02):i–iv. doi:10.4172/1948-5956.100000e2.
Verma SK, Bhadauria SS, Akhtar S. 2013. Review of nondestructive testing methods for condition monitoring of concrete structures. J Constr Eng. 2013:1–11. doi:10.1155/2013/834572.
Warfi R, Harto AW, Sardjono Y, Widarto W. 2016. Optimization of neutron collimator in the thermal column of Kartini Research Reactor for in vitro and in vivo
trials facility of boron neutron capture therapy using MCNP-X simulator. Indones J Phys Nucl Appl. 1(1):54. doi:10.24246/ijpna.v1i1.54-62.
Yilmaz D, Güzeldir B, Akkuş T, Öznülüer T. 2018. X- and gamma-ray irradiation effects on vanadium pentoxide thin films. Spectrosc Lett. 51(6):297–301. doi:10.1080/00387010.2018.1475397.
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